http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013227716-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7e45f23a7a90d0ece24b0328ce4180e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b082fa6af7a8fa59a24ce5083c84e49b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c5e523bae263054fbc6c0edd69013c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate | 2011-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_959ee39a4b450b1ac79b2ebf48c93188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a67cab5dedd9e56e9c57c0d69e452cd |
| publicationDate | 2013-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013227716-A1 |
| titleOfInvention | Methods and compositions for targeted protein degradation |
| abstract | Coronatine has been found to enhance binding of the JAZ1 degron to the Arabidopsis F-box protein COI1, and analysis of the JAZ1 degron sequence has resulted in the identification of specific peptide sequences that bind COI1 with high affinity in the presence of coronatine. Crystal structure analysis has determined that coronatine and JA-Ile enhance the interaction between COI1 and JAZ1 via binding to a specific binding pocket on COI1. Attachment of one or more JAZ1 peptide tags as disclosed herein to a target protein in a non-plant cell expressing Arabidopsis COI1 or a homolog thereof results in degradation of the target protein following addition of a molecule that binds the coronatine/JA-Ile binding pocket on COI1. Therefore, provided herein are compositions, methods, and kits for targeted protein degradation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113862296-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11078496-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017180720-A1 |
| priorityDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.