http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013210924-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cda4382b0099c31b63d4d7c08b35ed64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_544671b5c069e5be15dcec71f980f0d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5b0cb3a13a12fe836a96d161ae73a18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-661 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137 |
| filingDate | 2011-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_362af0f6a73162c4b784cce5efe11cb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7eed99e4d0ce914088d6d74b879e454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71ec4c7c529bd3dd90c22cc9d9662a89 |
| publicationDate | 2013-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013210924-A1 |
| titleOfInvention | Dosage Regimen of Diaryl Sulfide Derivatives |
| abstract | A compound of formula (I) wherein X is O, S, SO or SO 2 ; R 1 is halogen, trihalomethyl, —OH, C 1-7 alkyl, C 1-4 alkoxy, trifluoromethoxy, phenoxy, cyclohexylmethyloxy, pyridylmethoxy, cinnamyloxy, naphthylmethoxy, phenoxymethyl, —CH 2 —OH, —CH 2 —CH 2 —OH, C 1-4 alkylthio, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, benzylthio, acetyl, nitro or cyano, or phenyl, phenylC 1-4 alkyl or phenyl-C 1-4 alkoxy each phenyl group thereof being optionally substituted by halogen, CF 3 , C 1-4 alkyl or C 1-4 alkoxy; R 2 is H, halogen, trihalomethyl, C 1-4 alkoxy, C 1-7 alkyl, phenethyl or benzyloxy; R 3 H, halogen, CF 3 , OH, C 1-7 alkyl, C 1-4 alkoxy, benzyloxy, phenyl or C 1-4 4alkoxymethyl; each of R 4 and R 5 , independently is H or a residue of formula (a) wherein each of R 8 and R 9 , independently, is H or C 1-4 alkyl optionally substituted by halogen; and n is an integer from 1 to 4; or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof; or a compound of formula (II) wherein R 1a is halogen, trihalomethyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulifinyl, C 1-4 alkyl-sulfonyl, aralkyl, optionally substituted phenoxy or aralkyloxy; R 2a is H, halogen, trihalomethyl, C 1-4 alkyl, C 1-4 alkoxy, aralkyl or aralkyloxy; R 3a is H, halogen, CF 3 , C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio or benzyloxy; R 4a is H, C 1-4 alkyl, phenyl, optionally substituted benzyl or benzoyl, or lower aliphatic C 1-5 acyl; R 5a is H, monohalomethyl, C 1-4 alkyl, C 1-4 alkoxy-methyl, C 1-4 alkyl-thiomethyl, hydroxyethyl, hydroxypropyl, phenyl, aralkyl, C 2-4 alkenyl or -alkynyl; R 6a is H or C 1-4 alkyl; R 7a is H, C1 -4 alkyl or a residue of formula (a) as defined above, X a is O, S, SO or SO 2 ; and n a is an integer of 1 to 4; or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof, for use in a method of treatment, optionally of an autoimmune condition, wherein said compound of formula (I) or (II) is administered at a dosage lower than the standard daily dosage of said compound during the initial period of treatment and then is increased, optionally stepwise, up to the standard daily dosage of said compound. |
| priorityDate | 2010-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 173.