| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0cdf81b94a27a0a72890f62b8e04b6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_517ff793c312f1d2502ecae5491b2af5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39bd421148c99a2d51d04bc348d6cb7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2435f27612f84e2e2469256e8352fb7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2007-0039
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B65D25-00 |
| filingDate |
2011-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f090a732121c83608df4668b1bac16b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe6990914c961d3adaefbc5b824ae273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86156d135a57cf1735893429d11c9585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dacb78d728e433e6d2578417af50e386 |
| publicationDate |
2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013204166-A1 |
| titleOfInvention |
Custom designed microbubble contrast agents and techniques of ultrasound delivery optimized for gene therapy |
| abstract |
The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672553-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11273329-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9302124-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10656025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10166379-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10028723-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10926074-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11740138-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10322178-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9358023-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11058901-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014316329-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111254162-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9192566-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10232196-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10441820-B2 |
| priorityDate |
2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |