| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2fe1a4cd040c2d3a7fe3b73fd1222759 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-06004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate |
2013-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b32c12329eb7c20d80fa5a1c3969207
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e27aaceaef866d4411b66ff90213787
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dfa428b6da02d6b55b5c913de10e83f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_871f8d3490a0e47c7a6fc65650f5c94e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c99c82784ecb1e1aafd33737022ddd0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbea009eabdf93d97fedb6c685ddf8c6 |
| publicationDate |
2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013202633-A1 |
| titleOfInvention |
Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance |
| abstract |
Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10472615-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10801018-B2 |
| priorityDate |
2012-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |