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filingDate 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2013189290-A1
titleOfInvention Vaccine for the prevention of breast cancer relapse
abstract The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as recombinant human GM-CSF, and the E75 peptide at an optimized dose and schedule. The methods further comprise administering an annual or semi-annual booster vaccine dose due to declining E75-specific T cell immunity. The invention also features vaccine compositions for use in the methods.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015127027-A1
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