http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013183334-A1

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filingDate 2013-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2013183334-A1
titleOfInvention Lentiviral vectors and methods of use thereof
abstract The compositions and methods described herein relate to lentiviral vectors that can be used to generate virions/viruses that exhibit enhanced infectivity with respect to monocyte-derived macrophages (MDM) and dendritic cells (MDDC). Such compositions and methods further relate to production of virions/viruses that can be used as components of vaccines that effectively stimulate innate immune responses. In a particular embodiment, compositions and methods described herein relate to production of virions/viruses that can be used as components of human immunodeficiency-1 (HIV-1) vaccines administered to stimulate innate immune responses to HIV-1.
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