| abstract |
The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from —(CH 2 ) n —*, —(CH 2 CH 2 O) n CH 2 CH 2 —*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from —COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives. |