| abstract |
Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis can be treated with a compound selected from an incretin mimetic and a dipeptidyl peptidase IV inhibitor in combination with a Compound of Formula I or a pharmaceutically acceptable salt thereof n n n n n n n n n n Three of R 1 , R 2 , R 3 , R 4 and R 5 are hydrogen and the remainder are independently selected from the group consisting of hydrogen, halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; and m is 0, 2 or 4. R 6 is hydrogen, O or hydroxy, and X is —OR 7 , wherein R 7 is hydrogen or alkyl having from 1 to 3 carbon atoms; or R 6 is hydrogen, and X is —NR 8 R 9 , wherein R 8 is hydrogen or hydroxy and R 9 is hydrogen, methyl or ethyl. When X is —NR 8 R 9 , hydroxy none of R 1 , R 2 , R 3 , R 4 and R 5 is hydroxy. |