| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_035518ce91526416eda9bcb6ab8faa19 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01F17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-00 |
| filingDate |
2011-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190db8969e80356d59ea5be0614b25b1 |
| publicationDate |
2013-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013116429-A1 |
| titleOfInvention |
Gadobutrol Preparation in a One-Pot Process by means of DMF Acetal and N-Methylimidazole |
| abstract |
A process is described for preparation of the gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane “gadobutrol=Gadovist®” in a one-pot process by means of DMF acetal and N-methylimidazole. Gadovist is a gadolinium-containing contrast agent for nuclear spin tomography and has been approved since 2000 in Germany in the indication “contrast amplification in cranial and spinal magnetic resonance tomography”. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10435417-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11091449-B2 |
| priorityDate |
2010-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |