| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64e55b797ad58f5f211ad33b9067535f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate |
2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe598e554ac3dc2004edd7fff4c76340 |
| publicationDate |
2013-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013102485-A1 |
| titleOfInvention |
Method of Determining a Diseased State in a Subject |
| abstract |
A method includes a step of identifying candidate miRNA-mRNA complexes where an mRNA sequence from a set of mRNA sequences stably hybridizes to a miRNA from a set of miRNA sequences. The candidate miRNA-mRNA complexes have stably hybridizing sub-regions of a downstream region to portions of a 5′ miRNA section and stably hybridizing sub-regions of an upstream region to portions of a 3′ miRNA section. Candidate mRNA and/or miRNA sequences are identified as sequences that form candidate microRNA-mRNA complexes. Differences between expression levels between candidate mRNA and/or miRNA sequences in subjects having a disease and subjects not having the disease are determined for each candidate mRNA and/or miRNA sequence to identify candidate mRNA sequences and/or miRNA sequences. The expression levels of each candidate RNA disease markers are compared to controls such that deviation of expression levels of the candidate RNA disease markers from the controls indicates presence of the disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822663-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-3070047-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434531-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019030461-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11447813-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10457995-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10837063-B2 |
| priorityDate |
2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |