| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70373a0ba301548dbf80f6d04c79728e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8bd3cca41a52b0f9b363fce1acde8c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5432
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-221
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0087
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M37-0092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6925 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2011-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8582b61937408e27c9a535bea4597249
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_438980f226ce10b4ae77118dc5065619 |
| publicationDate |
2013-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013101521-A1 |
| titleOfInvention |
Methods devices and systems of preparing targeted microbubble shells |
| abstract |
Targeted microbubbles are generated by post-labeling buried ligand microbubbles. According to embodiments, buried ligand microbubbles are created with steric brushes protecting functionalized polymer tethers. Ligands were attached to the functionalized tethers by diffusion of ligands of a small size through the steric barrier. The steric barrier was substantially capable of hindering access to the tethers by larger molecules. The embodiments disclosed include methods for creating microbubble batches that can be loaded with selected ligands, for titrating the targeting ligands thereby to reduce waste and cost, and for using resulting buried ligand molecules for medical purposes. |
| priorityDate |
2010-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |