Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_627dcf7b189c2016cd542dca585e0c1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2d79d3b715bfcea810e4a6184a176ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24622ef1beb552acca9ab20097311993 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8c33f69f034fe3051d8da1009c0df5d |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-495 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 |
filingDate |
2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d475769592b2595fef005e94f292d8b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_927b2ae967b97017e467a9a36e856835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c8fda018431f7ae9402f22f88be3e6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edb7fa210c6b3707e80ceb8989d23cb4 |
publicationDate |
2013-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2013089500-A1 |
titleOfInvention |
Antagonists of ligands and uses thereof |
abstract |
The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I: n (< bd 1>linker1) k -[{< bd 1>-linker2-< bd 2>linker3 f -} n -(< bd 3>) m -(linker4-< bd 4>) d ] h , n where:n n and h are independently greater than or equal to 1; d, f, m and k are independently equal to or greater than zero; bd's are polypeptide binding domains having an affinity for the same member of the TGF-β superfamily; and, linkers are unstructured polypeptide sequences. |
priorityDate |
2007-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |