| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_627dcf7b189c2016cd542dca585e0c1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e1018b924ad1e238642eaad9d2172a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24622ef1beb552acca9ab20097311993
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f0eeb50a3777121c35f5d0a29ee362b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8c33f69f034fe3051d8da1009c0df5d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-495 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate |
2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9c1a7aa9f5c2150beae718ca6711f9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_823d517f7f4ddb2145bb9fea12c1e08b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f073b2e121889618de9454e17a1e7d12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b896fb40ae0582b9174dd01f5eccdef |
| publicationDate |
2013-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013089499-A1 |
| titleOfInvention |
Antagonists of ligands and uses thereof |
| abstract |
The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I: n (<bd1>-linker1) k -[{<bd1>-linker2-<bd2>-linker3 f -} n -(<bd3>) m -(linker4-<bd4>) d ] h , n where:n n and h are independently greater than or equal to 1; d, f, m and k are independently equal to or greater than zero; bd's are polypeptide binding domains having an affinity for the same member of the TGF-β superfamily; and, linkers are unstructured polypeptide sequences. |
| priorityDate |
2007-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |