http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013085282-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c8a359189bbd7c4a99dbb6ab3a231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baba42d23b83a266752277a8f68d867b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-10 |
| filingDate | 2011-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45993fe102deb20bf99d4e0d26ed0471 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f757e21b74f33f51c60124568f4dc2ce |
| publicationDate | 2013-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013085282-A1 |
| titleOfInvention | Method for producing 3-substituted-4-fluoropyrrolidine derivative |
| abstract | An inexpensive and industrially advantageous method for producing optically active syn-3-(N-substituted-aminomethyl)-4-fluoropyrrolidine which may be an intermediate for producing pharmaceuticals is provided. The present invention relates a method for producing a syn-1-protected-4-fluoro-3-(N-substituted-N-nitrobenzenesulfonyl)pyrrolidine derivative or it's enantiomer, or their salts comprising the process of fluorinating a compound represented by the general formula (6) (in the formula, PG 1 represents a protecting group for an amino group, R 1 represents a C1 to C6 alkyl group which may be substituted or a C3 to C8 cycloalkyl group which may be substituted, and Ns represents a 2-nitrobenzenesulfonyl group or a 4-nitrobenzenesulfonyl group) or it's enantiomer using a nucleophilic fluorinating agent and an organic base having an amidine or guanidine structure. |
| priorityDate | 2010-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 454.