| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6924735966889445ab6e56c1bd393f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de1520433c63461e6f0f88825ced9e0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f184e3b888cbaa6c3dc905ec17d5e2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d3f5520e37cbb6482879df9dacf968e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fbe52c96a813fc3204a72f2157359ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12deb59d87011ed49f707d6f01e69d30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d5d33173c75c573683d564e8b03d423
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b45b94accd546cdedd78214c8abe01ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_723ef0c931261662068c6639ae0bbcfd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cb3a4131dd7c3801c47cd91b8440428 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-70 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-58 |
| filingDate |
2011-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa0d2fbfbb5667a1a070c6d190148e35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36092bac2c28b81f263a55df6f420285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b95b2484e2d2b31c10eba18893a33ac0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ee44551d6e76aca46d341437c2bcafe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86d4d6cc3cd49a584e0a44afb59614b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14fe4db689e68e7f9b7a489796ca6e55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9355935d566dceed484a409ca9db6f2 |
| publicationDate |
2013-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013060550-A1 |
| titleOfInvention |
Method of toxicological evaluation, method of toxicological screening and associated system |
| abstract |
The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102014224916-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10304671-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110044997-A |
| priorityDate |
2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |