| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41ecfe3430156a85b1d11fcc2a98d056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b16e2ca97c9f369665427b635f1b2eb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_295309dfb77ee3597f220dd5df49fbba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82b18725d8f851ee4050337636ea1c9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_758e58e8a2be75c2572bc5520cbcd32c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-75 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
| filingDate |
2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_913c9564134b5909a792a3758bc3148d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f859a94608bf727343d8aa4ec68f3e59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eccaa624ea8cc7ca5d1fc0b4b19006c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70e90c57feb3a517849f0dce19964bb0 |
| publicationDate |
2013-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013053546-A1 |
| titleOfInvention |
Use of Anticoagulants in the Production of Recombinant Proteins in the Milk of Transgenic Animals |
| abstract |
The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin. |
| priorityDate |
2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |