| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_261820c1464b2ef0a6c572434b633e12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb453ce13544a253f6a66d3b0c42d3b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbd19457179e16605ccccec7b4c13217 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B10-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-48 |
| filingDate |
2010-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ebec5555306e852a0722d7a6f397b1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84f180ed82c07fcf27830ec31d31dc51 |
| publicationDate |
2013-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013053543-A1 |
| titleOfInvention |
Peptide clearing agents |
| abstract |
A peptide clearing agent is provided for clearance of a conjugate of an enzyme and a binding molecule which binds specifically at a target location from a non-target location in a subject. The peptide clearing agent binds the active site of the enzyme. The peptide also binds to the asialoglycoprotein receptor expressed by hepatic cells to facilitate clearance through the liver. The peptide may be glycosylated to facilitate clearance through the liver by binding to hepatic cells expressing an asialoglyco-protein receptor. Typically, the peptide prevents or inhibits enzyme activity upon binding to the enzyme and is not substantially modified by the enzyme activity. The peptide may be based upon the dipeptide amino-naphthoic acid (ANA)-glutamate (GIu) and may comprise the amino acid sequence serine (Ser)-Alanine (Ala)-amino-naphthoic acid (ANA)-glutamate (GIu). In such cases, the enzyme of interest is typically CPG2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9850296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800838-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253579-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11654188-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10471155-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878048-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10940209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10392437-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11666638-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10919963-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10046056-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10946079-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9901646-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9901645-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10821157-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10953101-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11246943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846328-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9814780-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265416-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265415-B2 |
| priorityDate |
2009-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |