| abstract |
The present invention provides a novel benzodiazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The benzodiazepine compound of the invention is represented by General Formula (1) n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen or lower alkyl; R 2 and R 3 may be linked to form lower alkylene;n nA 1 is lower alkylene optionally substituted with one or more hydroxy; andn nR 5 is group represented byn n n n n n n n n n n wherein R 6 and R 7 are each independently hydrogen or organic group;n nX A and X B are each independently bond, lower alkylene, etc. |