| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c298f0e7cdc11914dc76e17eced40b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3b3b10767bc43ed4aa9d9ba69189913
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ccf9fc930e0607947e4f7acb393a795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49d7635f6251d9b3dd5dbb9c0539e19e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03dbd4a28db5f9da3f2809b3d31f66cc |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-36 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0786
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-90 |
| filingDate |
2012-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28066361d9ff55da6e5e6854a68d1e79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6406b22f58dfb7adf5a2fcba33968817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26efcd55c5b4114a4129130a7010fbbb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fba1f940f9efb9cad7d28e97cce3a5d |
| publicationDate |
2013-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013040829-A1 |
| titleOfInvention |
In vitro model of latent mycobacterial infection |
| abstract |
A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level of carbon dioxide and a relatively low gas phase oxygen level. An in vitro model of mycobacterial infection employs macrophages induced from THP1 cells which are then infected with Mycobacterium. The infected macrophages are grown under hypoxic conditions to induce latency in the mycobacteria. The in vitro model of infection is useful in evaluating compounds for activity against latent mycobacteria. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-038371-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2707941-C1 |
| priorityDate |
2007-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |