http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013040390-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd54e47253748563d01fd8c440437fb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cbf2758ac98e8f8100ecf153edada21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5978cdda6713d61f3b8e68ac26b3a0ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f80a2732a3331b97f7a2120cbe271b3a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-999 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2010-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98330eabc12fd8c6825e060a016f9c50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a414998fa3cb82786d1b25b3d5cc86f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90dc9aab12377e651db6e02524601dd5 |
| publicationDate | 2013-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013040390-A1 |
| titleOfInvention | Culture medium supplement and use thereof |
| abstract | The present invention provides a chemically defined culture system, by which induced pluripotent stem (iPS) cells are obtained with high efficiency. The culture medium supplement of the present invention includes vitamin C and a glycogen synthase kinase-3 inhibitor; another culture medium supplement of the present invention further includes, in addition to vitamin C and the glycogen synthase kinase-3 inhibitor, vitamin B12, insulin, a receptor tyrosine kinase, and an anti-oxidant; and the culture medium supplement of the present invention may further be a mixture of the above two culture medium supplements with a serum replacement cell growth promoter. The present invention further provides a complete culture medium for iPS cells, which is formed by one or more of a basal culture medium, serum, and a serum replacement supplement, and the above culture medium supplements, or formed only by the above culture medium supplements and a basal culture medium. The culture system of the present invention is a chemically defined culture system free of serum and contamination from animal source, by which the iPS cells are obtained with high efficiency. The culture system maintains the growth and proliferation of the cells in conversion of somatic cells to iPS cells in absence of feeder cells, significantly accelerates the iPS cell induction process, and greatly improves the induction efficiency of somatic cells into iPS cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9481861-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3177302-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021263241-A1 |
| priorityDate | 2010-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 714.