Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36551c8d08ce624a57ba65202923ac26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ac4560afea7c312447ea9a2547d6149 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fe989d354816244a92a4e8a07220198 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
filingDate |
2012-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4b2f7687b863fdd3f0afe4bd2960099 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9250a4446e91c1a99997ae867b64d78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19882200a771ec0ff46d50c31b8e2319 |
publicationDate |
2013-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2013034914-A1 |
titleOfInvention |
Fluorescence-based approach to monitor release factor-catalyzed termination of protein synthesis |
abstract |
Provided are probes comprising a class 1 release factor conjugated to a fluorescent label and methods of making the probes. Also provided are methods for detecting conformational changes in ribosomes and associated molecules, such as class 1 release factors. In addition, methods of identifying a compound for reducing nonsense-mediated decay of mRNA and/or for inhibiting termination of protein synthesis at a premature stop codon, are described. Methods of assaying RF3 activity are also included. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016082402-A1 |
priorityDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |