| abstract |
In a first aspect, the present invention relates to a method for prevention or treating memory impairment and/or a neurodegenerative condition, disorder or disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound targeting a miRNA or any precursor, or targeting the activity of said miRNA or any precursor thereof. In particular, the present invention relates to a method wherein the targeted miRNA is miR-34. Moreover, the present invention relates to a method for improving memory functionality in a subject suffering from memory loss, said method comprises the reduction or reducing the level of miR-34 levels or precursor molecule levels in brain tissue of said subject administering to the subject a therapeutically effective amount of a compound targeting miR-34 or any precursor thereof. n Moreover, the present invention relates to a method of inducing memory loss in an individual comprising administering to said individual an effective amount of one or more compounds having the functionality of miR-34, in particular of miR-34c or any precursor thereof. In addition, a method for diagnosing or predicting memory impairment and/or neurodegenerative condition, disorder or disease is provided. Finally, the present invention relates to a pharmaceutical composition containing a compound targeting miR-34 or precursor molecules thereof. |