| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28ff820423c23d0414d1420995fa73f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20fef70df872bcdea74c1b83a70db07f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-036 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
| filingDate |
2012-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078f76cd07c69a8a43c7ed7439ec1528 |
| publicationDate |
2013-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013018177-A1 |
| titleOfInvention |
Production of Sialylated N-Glycans in Lower Eukaryotes |
| abstract |
The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities (such as those involved in sialylation) to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10113164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10676581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10513724-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015100058-A1 |
| priorityDate |
2003-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |