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publicationDate 2013-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2013014567-A1
titleOfInvention Chromatography apparatus having diffusion-bonded and surface-modified components
abstract A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
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