| abstract |
Disclosed are compounds of the formula n n n n n n n n n n or a pharmaceutically acceptable salt or solvate thereof, wherein n R 1 is n n n n n n n n n n R is —C(O)—N(R 27 )(R 28 ) or n n n n n n n n n n and the remaining variables are as defined in the specification. n Also disclosed are pharmaceutical compositions comprising the compounds of formula I. n Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. n Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody. |