| abstract |
Compounds of Formula I or II, and methods of making and using thereof, are described herein. n n n n n n n n n n n n M represents a macrolide subunit, n E is a C 1-6 group, optionally containing one or more heteroatoms, n D is an alkyl or aryl group, n A is a linking group connected to D, n B is an alkyl, alkylaryl or alkylheteroaryl spacer group, n ZBG is a Zinc Binding Group, n R 1 , R 2 and R 4 are independently are selected from hydrogen, a C1-6 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-6 alkanoate group, a C 2-6 carbamate group, a C 2-6 carbonate group, a C 2-6 carbamate group, or a C 2-6 thiocarbamate group, n R 3 is hydrogen or —OR 5 , n R 5 is selected from a group consisting of Hydrogen, a C 1-6 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, C 1-6 alkanoate group, C 2-6 carbamate group, C 2-6 carbonate group, C 2-6 carbamate group, or C 2-6 thiocarbamate group. |