http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012316333-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_069c23abff57b977203b65b5c223cc10 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-008 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
filingDate | 2010-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f35ea3efdd0c9ad0afb5164f93153f40 |
publicationDate | 2012-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2012316333-A1 |
titleOfInvention | Preparation method of drospirenone |
abstract | The present invention discloses the preparation method of drospirenone. 3β,5-dyhydroxy-6β,7β,15β,16β-dimethylene-5β-androstane-17,20-epoxy is taken as the raw material. It is subject to oxidization of the hydroxyl at the 3 rd position, ketalization of 3-ketone group, condensation reaction and deesterification to obtain carboxylic acid lactone, sulfonation of the hydroxyl at the 5 th position, and deketalization and desulphonation in the reaction system of glacial acetic acid and sodium acetate to produce the 3-keto-4-alkenyl compound, thus obtaining drospirenone. The preparation method of the invention has high intensification, reaction specificity, less by-products and high yield of products in each step, thus overcoming the disadvantages of low yield and unstable quality. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104163846-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108025014-A |
priorityDate | 2010-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.