| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ac89cad113b5cc0515d369c85079ffd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e16bd282bf65146da909ac92b80303f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc84bb2fb470bf844147368b8d3835a3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
| filingDate |
2012-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbe59c5a9eb7381462cf231d8da958b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe4b369d133b32def3d81758fd52e436 |
| publicationDate |
2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012283444-A1 |
| titleOfInvention |
Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer |
| abstract |
The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017207519-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019165298-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3252055-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111836813-A |
| priorityDate |
2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |