| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d60813bf897ef5a62663bc9e6ef135ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29c01bc5575bc999a1f7126c3986326a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f313be5d80164853fa7c3fead707684b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_157eaf2c3e837a2a033c3bd314b3adf7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_649bd2026a4a8b02fdd4747276d3d228
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0da46e841bf6abf3db47b0c268eeb456
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc835da2975ea6555da51d969aa58b35 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10361
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10332
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36161 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-768 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-768
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2010-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c1c316b52a4f0c393c640a8b3a60262
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dc7052214ca04ad3cccf9ca20ca35db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7036f40b907f853f79c13b2e956a1871
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea53e928bc52aa4de51eec910311f4b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_963c19cff3cfaca7e297eae9f0b2b206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfb65bf6a19b3162f22f3e43a00e4fd4 |
| publicationDate |
2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012282225-A1 |
| titleOfInvention |
Method and composition for creating conditional lethality for virus mutants and for eliminating the viability of an eukaryotic cell |
| abstract |
Viral vectors are potential tools for eliminating the viability of eukaryotic cells in anti-cancer therapies since they can efficiently destroy the cancer cells and trigger an immune response against tumours. Typically viruses are not specific to cancer cells and all methods known in art aiming to the construction of cancer-specific viruses suffer from serious problems. The present invention presents a universal method to overcome these problems and is usable for any DNA virus replicating in nucleus or for any layered vector of RNA viruses. In this method the viral gene expression and/or replication will be blocked by the introduction of one or more aberrantly spliced introns into crucial gene expression units of the virus or vector. Lethal effect of these mutations is reverted in a controlled manner by the delivery of splice-switch oligonucleotide (s) correcting the introduced defects and restoring the biological functionality of the virus or vector, including cytolytic properties. |
| priorityDate |
2009-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |