| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_657011521cc210bd2be5a9ffea7bd48c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a84a77ff369b0711477b28dfe2f20016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c66f1553ae03350503caba7cd466c2a7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5089 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 |
| filingDate |
2012-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a56af842fc7d7c213ed1fa1a884be44f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8eac7a1f60df2f50bccb9bebb535d34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe0d61e5e8b15e7c9cb613bfb35f8bd9 |
| publicationDate |
2012-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012276207-A1 |
| titleOfInvention |
Methods for preparation of lipid-encapsulated therapeutic agents |
| abstract |
Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019048631-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019048632-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019048645-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023099884-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3985118-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3594348-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022122872-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023104964-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019197845-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023170435-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4183882-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020208361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022200810-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4242307-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4233880-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015075557-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4219715-A2 |
| priorityDate |
1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |