http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012252741-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60d2134a44f2b4765a9a1a36828c1d8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_338b1888143ef4e543c31d0e90fec30d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b76cdc7158067842a9b6006996e7913 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7d68c0925ad0c9068f497500f781377 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2012-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3afa6fadac1f76bd1454a032aca1e429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c008d0270eaf3ac95c47ac3732f38c28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2541d2a5a2560b37a3f1fd16bc0cc570 |
| publicationDate | 2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2012252741-A1 |
| titleOfInvention | Novel semi-synthetic glycopeptides as antibacterial agents |
| abstract | Provided herein are semi-synthetic glycopeptides having antibacterial activity. The semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety with certain acyl groups; conversion of the amide group in amino acid-3 to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring to certain substituted amides. Also provided herein are pharmaceutical compositions comprising the semi-synthetic glycopeptides, and methods of use of the semi-synthetic glycopeptides for the treatment and/or prophylaxis of diseases, especially bacterial infections. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011015119-A1 |
| priorityDate | 2008-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 2101.