| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6072b910839b9605ef41c8d78e43bccf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e5c257ec6d8d4aff785f0793b4a0afb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25780b9019119a4359312bf5a73d1376 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate |
2012-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bad21e838e9b014f2ad232ee3521441
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f201d6d8aad5741a2b29df8b32778a67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e0288363e598ea8d9a0e9cc664fe661 |
| publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012252689-A1 |
| titleOfInvention |
Gene expression signature for wnt/b-catenin signaling pathway and use thereof |
| abstract |
The present invention relates to a novel set of 16 biomarkers, microarrays that provide for the detection thereof, an expression signature comprising 16 genes or a subset thereof, and the use thereof in determining the regulation status of Wnt/β-catenin signaling pathway. The regulation status of Wnt/β-catenin signaling pathway may be assayed based on the level of expression of one or more of these genes. The expression of these biomarkers may be used to evaluate Wnt/β-catenin pathway deregulation status; classify a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determine whether an agent modulates the Wnt/β-catenin signaling pathway; predict response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assign treatment to a subject; or evaluate the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015017545-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4039825-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014128142-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2767594-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022171456-A1 |
| priorityDate |
2011-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |