| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd9056d444abc5a2f87be0ad59f129e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcb3d9cd08b663d4530071e75777211f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2010-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b0f21adc02b22db5d406acfcbc252f4 |
| publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012251552-A1 |
| titleOfInvention |
Methods of generating improved antigen-binding agents using chain shuffling and optionally somatic hypermutation |
| abstract |
The invention relates to a method of identifying a desired antigen-binding agent that binds to an antigen of interest. The method utilizes a combinatorial approach wherein a nucleic acid sequence encoding a polypeptide comprising a first component of an antigen-binding agent is provided to a population of cells together with a library of nucleic acid sequences, each of which encodes a polypeptide comprising a second component of an antigen-binding agent. The method further comprises subjecting one or more of the nucleic acid sequences encoding a first component, a second component, and/or an identified antigen-binding agent to somatic hypermutation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014132131-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11536715-B2 |
| priorityDate |
2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |