| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4f1db17a797ce9e3674095870a57cfd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a07afd9ddd92b6c5c2dba1bccfff4a46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_610be997d06cf62566f7249e0a592863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b002fb27b0cc02bc74bc06b0d6f27e16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d16c73833a9ec380ce18fa4a3b5eefb2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d08c49817304cc1ac93cd145841dfe6c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4826
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-04 |
| filingDate |
2010-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f4a11e3d0b2f5e16fdcfb83bc14493d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9ed7e8d6bfd67b17784465e8dc19cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a5be857c8ecd39380422a788ede196a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbeccd38361ca9951b68bdbe999ecbca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_375c39156b9048f0b4e9edc1af09c779 |
| publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012251516-A1 |
| titleOfInvention |
Pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent |
| abstract |
The present invention generally relates to pharmaceutical compositions containing a protease proenzyme and use thereof for treating cancer. The pharmaceutical compositions are directed to compositions comprising a protease proenzyme and an active agent, the composition being capable of providing a multi-functional approach for treating cancer. The pharmaceutical compositions are also directed to compositions comprising a first and a second protease proenzyme capable of activation at or near a surface of a tumour cell to enhance cell-to-cell adhesion of tumour cells, effect proteolysis of tumour cells, or induce tumour cell apoptosis, differentiation or immunorecognition, wherein the first protease proenzyme is chymotrypsinogen and the second protease proenzyme is trypsinogen. The pharmaceutical compositions are also directed to compositions comprising a first and second active agent each capable of inducing intracellular activity in tumour cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9907786-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019134166-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11185587-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10092550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9402834-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11376313-B2 |
| priorityDate |
2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |