| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4722835ed2d01718e0ab6caa5af27a32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cb14d894cd60d9943bd572e99fa8af8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efcf1447561216a718a5a729fb82582b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3a1fbf1dce23cb388b673d1ab23a3fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634f9eaf572cc875324ed64fa6f7bc77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83199d4eb5f6c4cb5ab2236af07e5718 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2033-0093 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-386
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-71 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01J3-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01J49-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-38 |
| filingDate |
2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a58d27c23fbd48c01ec1d6ab70c141b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_853154f065571159c24cb7692ecb9ea3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40562faa8d4465ba4167158e6f4ceca0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00441926fe8337a548b470382b32fbe |
| publicationDate |
2012-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012229804-A1 |
| titleOfInvention |
Borosilicate glassware and silica based qma's in 18f nucleophilic substitution: influence of aluminum, boron and silicon on the reactivity of the 18f- ion |
| abstract |
Aluminum, boron and silicon were identified as potential leachables from borosilicate glassware and a silica based QMA during handling of aqueous 18 F. The addition of only 0.4 ppm aluminum as AlCl 3 in the eluent vial resulted in a strong reduction in the labeling yield of a model [ 18 F]fluoride S N 2 reaction (from 80 to 40% incorporation). The addition of boron as KBO 2 and silicon as NaSiO 3 did not result in any significant decrease in labeling yield. Interestingly, there was an interaction effect between AlCl 3 and KBO 2 in which the negative effect from AlCl 3 on labeling yield was counteracted by KBO 2 . The present invention demonstrates that aluminum and boron from borosilicate glassware have a strong influence on the labeling yield in nucleophilic S N 2 reactions with n.c.a [ 18 F]fluoride. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016168960-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111189902-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9803454-B2 |
| priorityDate |
2009-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |