http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012215154-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25b52fad4e76bb153df41bb31200ed77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed1db8d9db39150901bb8dcc4f867b41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9edc017ca5ab938ae99016ef9696712a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc06cad2b58bbfcc30e3c96a6eb6c926 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5a3388e24e066f43d21d626fe1c14f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-062 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-66 |
| filingDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b316c2c7e7f776d9656955f83daea7e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_243c9ce98b8166218ed24232e4609fd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db41628f52f2bfe3fbff629414a9e87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d97c9a81e6ea3aae62e31a5501f1047 |
| publicationDate | 2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2012215154-A1 |
| titleOfInvention | Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof |
| abstract | The present invention provides a method of preparing a compound of formula 6 n n n n n n n n n n comprising:n (a) reacting a compound of formula 1 nn n n n n n n n n n n n n n with a compound of formula 2 n n n n n n n n n n n n n n n n n n n n to form a compound of formula 3 n n n n n n n n n n n n n n n n n n n n wherein X of formula 2 is Cl or OH; n n n (b) treating the compound formula 3 with Lawesson's reagent to form a compound of formula 4 n n n n n n n n n n n n n n n n (c) reacting a compound of formula 4 with potassium ferricyanide to produce a compound of formula 5 n n n n n n n n n n n n n n andn (d) performing catalytic reduction of nitro group of the compound of formula 5 with palladium on charcoal to generate the compound of formula 6,n nwherein R 1 of formulae 1-6 is H, C 1-10 alkyl, C 1-10 alkoxy or C 1-10 haloalkyl, and R 2 of formulae 1-6 is H or C 1-10 alkyl.n nn The present invention also provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R 1 and R 2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue; wherein growth of the tumor is inhibited. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3567036-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3424919-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016144678-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016144351-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017062729-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4105209-A2 |
| priorityDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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