| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4d518a6f9c8198fada447ba8dde5860
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_178f0c3dcee39c7dcb2fca53e0a68743
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6c5e84f6c3bb5d052f3f30ce908dc64 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0038
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J11-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate |
2011-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec083ff9944927412b54fa6446e1c425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e48b5590a0a8555e0cefb153208e41b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d3145bcb4f8e92fead2d5cdf1ab8c91 |
| publicationDate |
2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012214987-A1 |
| titleOfInvention |
Methods and compounds for preparing 3alpha-oxygen substituted steroids |
| abstract |
The invention relates to processes for preparing 3α-O-linked steroids including 3α-O-linked-androst-5-ene steroids and 3α-O-linked-5a-androstane steroids. In one process a 3α,4α-epoxy androst-5-en-17-one is predominately reduced at the epoxy moiety wherein reduction of the 3α,4α epoxy functional group occurs preferentially at position C4 with retention of configuration at position C3 to provide a 3α-O-linked-androst-5-ene steroid. In another process, conditions are provided for inversion of configuration of a 3β-hydroxy-androst-5-ene steroid by the Mitsunobu reaction to provide a 3α-O-linked-androst-5-ene steroid with reduced amounts of 3α,5α-cycloandrostane side-product impurities. |
| priorityDate |
2010-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |