| abstract |
Pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of formula [I]: n n n n n n n n n n wherein R 1 and R 2 are the same or different and each is an optionally substituted aryl group, etc.,n R 0 is hydrogen, an alkyl group, etc., E is —C(═O)— or —SO 2 —, R is a group of formula [i], [ii] or [iii], etc: nn n n n n n n n n n n n Ring A is a C 3-8 cycloalkyl group optionally fused to a benzene ring or a benzene ring, Q is a single bond or a methylene group, n Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom, etc., n R 3 is an alkyl group optionally substituted by an alkylthio group, n R 4 is hydrogen atom, an alkyl group, etc., n one of R A and R B is an alkyl group, etc., and the other is hydrogen, an alkyl group, etc., or a pharmaceutically acceptable salt thereof. |