Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_255c1a272aa322a848c7e685e5d7772b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_640603e17ee5effbc101dc60722f3078 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C381-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C381-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-194 |
filingDate |
2012-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6946459692a8a9bdaca8173dda25776e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bec9684319f97dc9e4e533c0cf8e5e4d |
publicationDate |
2012-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2012190820-A1 |
titleOfInvention |
Facile amide formation via s-nitroso thioacid intermediates |
abstract |
Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020130119-A1 |
priorityDate |
2011-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |