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publicationDate 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2012178703-A1
titleOfInvention Multimeric polypeptides of hla-g including at least two alpha3 domains and pharmaceutical uses thereof
abstract Multimeric polypeptides and pharmaceutical uses thereof; multimers comprising alpha3 peptides of an HLA-G antigen and methods of producing such multimers, pharmaceutical compositions comprising the same, as well as their uses for treating various diseases including organ/tissue rejection. n Said multimers comprise at least two monomers, each of said monomers being selected in the group consisting of a peptide P1 of formula X1−X2, wherein X1 represents a peptidic linker including a cysteine amino acid and X2 represents an alpha3 domain (SEQ ID NO:1) of HLA-G.
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