http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012172301-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd5ce695dad80299641796669a24a7da http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96bb4ccc6d89890a95c9730ee5e2ee97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8eafa809d0fc22fa56803e9c972def7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e62a1c58579d4f4ac363afacfe4c9714 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 |
| filingDate | 2009-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11c7994217dfde275bf911d0c9b081db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_376d6970eb439f640df57e75be08b5ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_767bdb8d8ae4c4d4bb44b62a5ed49454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2bdade5a13e5f9fec71c13899675810 |
| publicationDate | 2012-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2012172301-A1 |
| titleOfInvention | Pharmaceutical compositions comprising angiotensin-(1-9), derivatives thereof, or a vector expressing ace2, useful for treating cardiovascular, pulmonary, cerebral, and/or renal remodeling |
| abstract | The present invention relates to a pharmaceutical composition comprising an effective amount of angiotensin-(1-9) or derivatives thereof, and at least one pharmaceutical acceptable carrier, excipient, stabilizer, diluent, and/or adjuvant. Additionally, the present invention describes the use of the pharmaceutical composition and the angiotensin-(1-9) peptide or peptides derived thereof which are biological or chemical analogous for the manufacture of medicaments useful for preventing, reverting, inhibiting, and/or reducing cardiovascular, pulmonary, cerebral, or renal remodeling. Additionally, this invention also comprises a method for preventing, reverting, inhibiting, and/or reducing cardiovascular, pulmonary, cerebral, or renal remodeling comprising elevating blood and/or tissue concentration of angiotensin-(1-9) or derivatives thereof peptide via a pharmaceutical composition that contains a vector expressing ACE2, enzyme responsible for the endogenous production of angiotensin-(1-9). These vectors correspond to adenovirus, retrovirus, lentivirus, or adeno-associated viruses containing the gene that encodes ACE2. This invention allows to administer angiotensin-(1-9) or derivatives thereof via oral route, injections, pump continuous infusion, or elevate its levels in the organism through treatment with angiotensin I-converting enzyme inhibitors, angiotensin II receptor antagonists (ARA II), with Rho kinase inhibitors, with L-calcium channel antagonists, and/or with diuretics. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9333233-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9511055-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017066552-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9107870-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114380889-A |
| priorityDate | 2008-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 653.