| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1db53048b791fc0e0c4494876917dd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c501aa7f774905be88b3ef56811a59df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc408585f6863d7865c90ab9a4632135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3de43cce5ee71d338d5ae426f01a34d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6de4c5eab6cfd8e8f755f8c614b88d93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba1a2905599d22d5ff4945fcafc3603c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3053 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2011-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3565fc726e92e827bfa1d7b846f9288a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8339c7151641a70d0234f45cec45952f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb0c4d08f8118a5e0c2f19973c3d61c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d855ff22382e44209b64c1cc09407a1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeb78a06ae6511b9e7195c78f9fba923 |
| publicationDate |
2012-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012148598-A1 |
| titleOfInvention |
Methods for treating a tumor using an antibody that specifically binds grp94 |
| abstract |
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015036643-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10220091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113663078-A |
| priorityDate |
2010-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |