| abstract |
The present invention discloses methods and agents for diagnosing the presence or risk of development of ankylosing spondylitis (AS) in mammals, which are based on the detection of polymorphisms within any one or more of the ARTS-1 gene, the IL-23R gene, the TNFR1 gene locus, the TRADD gene locus, the IL-1R1 gene locus, the IL-1R2 gene locus, the CD74 gene locus and the chromosome loci 2P15, 2Q31.3 and 4Q13.1. The present invention also features methods for the treatment or prevention of AS based on the diagnostic methods. |