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filingDate 2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2012135030-A1
titleOfInvention Method of Producing Protein-Carbohydrate Vaccines Reduced in Free Carbohydrate
abstract This invention is directed to processes for reducing the level of free carbohydrate from a solution of protein-linked carbohydrate (conjugate) and non-linked carbohydrate. In this process, the conjugate is adsorbed to a hydrophobic membrane while the carbohydrate is not. The conjugate is then desorbed from the membrane, yielding a solution that is substantially reduced in free carbohydrate.
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