| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48b4ed0e3494fe589f9c2691405360f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_329427164a97ee78b2e1daf24060953a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff385ff15e3f1b168851fd16daedc104
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a13b258975924227b6c0cf3133ef6e68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bee69b560c8eef546c273bd31b01577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e23bb81179a2f6477d283dcad4becbfd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4208 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7c436532ecf2446cc30d4e08122e993
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f58407c1d4c8e803741ba720e8f43e07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b443e4240b3bbc4488f85fd44be9646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f010f6ab528f01a29989dd2f6d346235
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c45287a76ae78b2a9ff74e475d517880 |
| publicationDate |
2012-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012135012-A1 |
| titleOfInvention |
Trans-membrane-antibody induced inhibition of apoptosis |
| abstract |
Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11045544-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014144542-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973826-B2 |
| priorityDate |
1997-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |