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filingDate 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2012129192-A1
titleOfInvention Apparatus and Methods for Detection of Tumor Cells in Blood
abstract In one embodiment, the present invention provides the description of an inexpensive and disposable handheld device for detecting Circulating tumor cells (CTC) in blood called a handheld CTC detector (HCTCD). The HCTCD is capable of detecting less than 1 CTC per milliliter. The HCTCD consists of a dense array of high aspect ratio freestanding metallic nanoneedles, functionalized with antibodies that integrated within a microfluidic device and selectively capture and count (using electrical signal detection) the CTCs. By selecting a right functionalization protocol for the nanoneedles array, the HCTCD can be used for selective capturing a variety of rare cells that are mixed in human fluids.
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