| abstract |
The present invention relates to the use of a compound of the following formula (I), as an enzyme substrate for the detection of a peptidase activity or as a pH indicator: n n n n n n n n n n according to which:n Y 1 is a peptide, H or an alkyl; W 1 , W 2 , W 3 and W 4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U is N or N + R and V is CZ 6 N or N + R or else V is N or N + R and U is CZ 6 ; R is H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides,n nand salts thereof. |