| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1327e82773a11b9fa348df607135aaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25f874910e49bb676c35c675f91ece39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb81152625d9dd5720395d3b1a91700f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_991b0ddbfcbca94f2733f8aff3ad0b58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e843d3e1376c697b8327b19725622a8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-40 |
| filingDate |
2011-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e12e4e806d8c190dc3fbc894955edec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_353d8b1f116c08d53ca5a558b6a53a3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5469f7a1d5948d69bf72c0851dd08af6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbdb1617b455caa5f61c5af39b5ca209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e45f4acb5215d3f991a2987811854df2 |
| publicationDate |
2012-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012116117-A1 |
| titleOfInvention |
Process for the preparation of melphalan hydrochloride |
| abstract |
The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2970102-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-MI20130896-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014141294-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9963422-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9663450-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014141294-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014191426-A1 |
| priorityDate |
2010-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |