| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43d6972411aeef57c0b0df80124633b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7317808024e524eea40a6c5a5ad6a22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26dec4e8582310032515dc148fa9751a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2535-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0657
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01B13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B05D5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B05D1-36 |
| filingDate |
2010-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4eef00baeb6e7de29934d6616b16092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca194451fd3837e176c724d5ddb8e57 |
| publicationDate |
2012-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012094323-A1 |
| titleOfInvention |
Cardiomyocytes-containing device and method for manufacturing and using the same |
| abstract |
Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate ( 10 ) carrying a deformable stack ( 34 ), said stack being partially detached from the substrate by a cavity ( 32 ) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer ( 16 ), a second deformable layer ( 20 ) and a multi-electrode structure ( 18 ) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes ( 28 ) adhered thereto; and a liquid container ( 26 ) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017183224-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10414648-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018372724-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711248-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020076299-A1 |
| priorityDate |
2009-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |