http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012065395-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a430039304a12e0ccbe0bd28a72ea222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b2af339951888cdcdc51d1f850cca4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06ea6b40bb5be1432cd25a8c45ff90a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80ca1e02eebe8bd955cd90f08293f70a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc0f3dfc4f13a2fd2f582b1585a628bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74e4872d006c447c105fdc9bcaba5525 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
| filingDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc8086ec0d8bed50488229cd27ded74f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39b5ff9efb9c01ee43aae277e0d7334a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7149a240efe0198557abbea0c73c3b1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2539e0f178497e277f6fdb07eb9830ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3b2d607c0a5f2aa264349f805725556 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e9fb7e85dc9958db5b8a935179fd328 |
| publicationDate | 2012-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2012065395-A1 |
| titleOfInvention | 2,4 (4,6) pyrimidine derivatives |
| abstract | The present invention concerns the compounds of formula n n n n n n n n n n the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinn Z 1 and Z 2 represent NH; Y represents —C 3-9 alkyl-, —C 3-9 alkenyl-, —C 1-5 alkyl-NR 6 —C 1-5 alkyl-, —C 1-5 alkyl-NR 7 —CO—C 1-5 alkyl-, —C 1-6 alkyl-CO—NH—, —C 1-6 alkyl-NH—CO—, —C 1-2 alkyl-CO-Het 10 -CO—, —C 1-3 alkyl-NH—CO-Het 3 -,n -Het 4 -C 1-3 alkyl-CO—NH—C 1-3 alkyl-, —C 1-2 alkyl-NH—CO-L 1 -NH—, —NH—CO-L 2 -NH—, —C 1-2 alkyl-CO—NH-L 3 -CO—, —C 1-2 alkyl-NH—CO-L 1 -NH—CO—C 1-3 alkyl-, —C 1-2 alkyl-CO—NH-L 3 -CO—NH—C 1-3 alkyl-, —C 1-2 alkyl-NR 11 —CH 2 —CO—NH—C 1-3 alkyl-, Het 5 -CO—C 1-2 alkyl-, —C 1-5 alkyl-CO—NH—C 1-3 alkyl-CO—NH—, —C 1-5 alkyl-NR 13 —CO—C 1-3 alkyl-NH—, —C 1-3 alkyl-NH—CO-Het 27 -CO—, or —C 1-3 alkyl-CO-Het 28 -CO—NH—; n X 1 represents a direct bond, O, —O—C 1-2 alkyl-, —CO—C 1-2 alkyl-, —NR 16 —C 1-2 alkyl-,n —CO—NR 17 —, Het 23 -C 1-2 alkyl- or C 1-2 alkyl; n X 2 represents a direct bond, O, —O—C 1-2 alkyl-, —CO—C 1-2 alkyl-, —NR 18 —C 1-2 alkyl-,n —CO—NR 19 —, Het 24 -C 1-2 alkyl- or C 1-2 alkyl; n R 1 and R 5 each independently represent hydrogen, halo, C 1-6 alkyloxy- or C 1-6 alkyloxy- substituted with Het 1 or C 1-4 alkyloxy-; R 2 and R 4 each independently represent hydrogen or halo; R 3 represents hydrogen or cyano; R 6 , R 7 , R 13 , R 17 and R 19 represent hydrogen; R 11 represents hydrogen or C 1-4 alkyl; R 16 and R 18 represent hydrogen, C 1-4 alkyl or Het 17 -C 1-4 alkyl-; L 1 , L 2 and L 3 each independently represents C 1-8 alkyl optionally substituted with one or where possible two or more substituents selected from phenyl, methylsulfide, cyano, polyhaloC 1-4 alkyl-phenyl-, C 1-4 alkyloxy, pyridinyl, mono- orn di(C 1-4 alkyl)-amino- or C 3-6 cycloalkyl; n Het 1 , Het 2 , Het 17 each independently represent morpholinyl, oxazolyl, isoxazolyl, or piperazinyl; Het 3 , Het 4 , Het 5 each independently represent morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl; Het 10 represents piperazinyl, piperidinyl, pyrrolidinyl or azetidinyl; Het 22 represents morpholinyl, oxazolyl, isoxazolyl or piperazinyl wherein said Het 22 is optionally substituted with C 1-4 alkyl; Het 23 and Het 24 each independently represent a heterocycle selected from pyrrolidinyl, piperazinyl or piperidinyl wherein said Het 23 or Het 24 are optionally substituted with Het 22 -carbonyl; Het 27 and Het 28 each independently represent a heterocycle selected from morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006241-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8927547-B2 |
| priorityDate | 2004-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1908.